Article

TmCalculator: An R Package for Genome-Wide Nucleic Acid Melting Temperature Profiling and Multi-Omics Integration

2026-08-07

Abstract excerpt

Accurate calculation of nucleic acid melting temperature (Tm) underpins many molecular biology applications. Beyond single sequences, genome-wide Tm profiles capture intrinsic thermodynamic properties that can be leveraged to study biological processes at genomic scale. However, most existing Tm tools operate only at the sequence level and are incompatible with standardized Bioconductor data structures, such as GR...

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Literature Corpus work: eab01f82-9f57-52a5-ab79-3fc0307a9d7f
DOI: 10.20944/preprints202608.0543.v1

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