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Article

Machine learning based DNA melt curve profiling enables automated novel genotype detection.

BMC bioinformatics - 10 May 2024

Boussina Aaron, Langouche Lennart, Obirieze Augustine C, Sinha Mridu, Mack Hannah, Leineweber William, Aralar April, Pride David T, Coleman Todd P, Fraley Stephanie I

Abstract excerpt

Surveillance for genetic variation of microbial pathogens, both within and among species, plays an important role in informing research, diagnostic, prevention, and treatment activities for disease control. However, large-scale systematic screening for novel genotypes remains challenging in part due to technological limitations. Towards addressing this challenge, we present an advancement in universal microbial...

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Identifiers

PMID: 38730317
DOI: 10.1186/s12859-024-05747-0
PMCID: PMC11088152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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