Article
Kinesin walks hand-over-hand.
Science (New York, N.Y.) - 30 Jan 2004
Yildiz Ahmet, Tomishige Michio, Vale Ronald D, Selvin Paul R
Abstract excerpt
Kinesin is a processive motor that takes 8.3-nm center-of-mass steps along microtubules for each adenosine triphosphate hydrolyzed. Whether kinesin moves by a "hand-over-hand" or an "inchworm" model has been controversial. We have labeled a single head of the kinesin dimer with a Cy3 fluorophore and localized the position of the dye to within 2 nm before and after a step. We observed that single kinesin heads...
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