Article

Cross-Population Core SNPs for Human Height: Identification from Polygenic Score Weights and Multi-Level Functional Validation

2026-04-29

Abstract excerpt

<title>Abstract</title> <p> Background Polygenic scores (PGS) for complex traits show reduced predictive accuracy in populations divergent from the training cohort. Whether a core subset of variants maintains consistent importance across ancestries remains poorly characterized. Here, we propose Cross-Population Core SNPs (CPCS) — variants that consistently occupy extreme PGS weight rankings across multiple ance...

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Literature Corpus work: ea85c9a1-719d-52c3-82e1-19dbf4c539d3
DOI: 10.21203/rs.3.rs-9412948/v1

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