Article
A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Levine Morgan E, Langfelder Peter, Horvath Steve
Abstract excerpt
Polygenic scores are useful for examining the joint associations of genetic markers. However, because traditional methods involve summing weighted allele counts, they may fail to capture the complex nature of biology. Here we describe a network-based method, which we call weighted SNP correlation network analysis (WSCNA), and demonstrate how it could be used to generate meaningful polygenic scores. Using data on...
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