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Article

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice.

CNS neuroscience & therapeutics - 1 Dec 2018

Feng Jie, Wang Jing-Xue, Du Ye-Hong, Liu Ying, Zhang Wei, Chen Jing-Fei, Liu Yuan-Jie, Zheng Min, Wang Ke-Jian, He Gui-Qiong

Abstract excerpt

BACKGROUND: Activated microglia-mediated inflammation plays a key role in the pathogenesis of Alzheimer's disease (AD). In addition, chronic activation of NLRP3 inflammasomes triggered by amyloid β peptide (Aβ) in microglia contributes to persistent neuroinflammation. Here, the primary goal was to assess whether Dihydromyricetin (DHM), a plant flavonoid compound, is effective therapies for AD; it is crucial to...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29869390
DOI: 10.1111/cns.12983
PMCID: PMC6282966

Genes

APP
NLRP3
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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