Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation.

PLoS genetics - 12 Jan 2007

April Craig S, Barsh Gregory S

Abstract excerpt

Genetic variation at the melanocortin 1 receptor (MC1R) is an important risk factor for developing ultraviolet (UV) radiation-induced skin cancer, the most common form of cancer in humans. The underlying mechanisms by which the MC1R defends against UV-induced skin cancer are not known. We used neonatal mouse skin (which, like human skin, contains a mixture of melanocytes and keratinocytes) to study how pigment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epidermis
Share to Genes, Neoplasm
Share to Melanocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pigmentation

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Melanocortin, Type 1

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 17222061
DOI: 10.1371/journal.pgen.0030009
PMCID: PMC1774588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation.PMID 17222061Read ↗

Human Determinants and the Role of Melanocortin-1 Receptor Variants in Melanoma Risk Independent of UV Radiation Exposure.Semantic proximity Read ↗

UV Radiation and the SkinSemantic proximity Read ↗

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.Semantic proximity Read ↗

The Genetics of Sun Sensitivity in HumansSemantic proximity Read ↗

Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention.Semantic proximity Read ↗

Melanin content and MC1R function independently affect UVR‐induced DNA damage in cultured human melanocytesSemantic proximity Read ↗

MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA RepairSemantic proximity Read ↗

The Melanocortin 1 Receptor and the UV Response of Human Melanocytes—A Shift in Paradigm<sup>†</sup>Semantic proximity Read ↗

MC1R and the response of melanocytes to ultraviolet radiation.Semantic proximity Read ↗

Mechanism of UV-related carcinogenesis and its contribution to nevi/melanomaSemantic proximity Read ↗

Melanocortin-1 receptor (MC1R): a review for dermatologists.Semantic proximity Read ↗

Distinctive molecular responses to ultraviolet radiation between keratinocytes and melanocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.