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Article

MC1R and NR4A receptors in cellular stress and DNA repair: implications for UVR protection.

Experimental dermatology - 1 Jul 2014

Yin Kelvin, Sturm Richard A, Smith Aaron G

Abstract excerpt

Ultraviolet radiation (UVR) is the most common mutagen that melanocytes are exposed to. UVR causes a diverse range of DNA photolesions contributing to genome instability and promotes melanoma and non-melanoma development. Melanocytes are pigment-producing cells that synthesise the photoprotective melanins when the melanocortin-1 receptor (MC1R) is activated. MC1R is a G-protein-coupled receptor expressed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Receptor Subfamily 4, Group A, Member 2

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Identifiers

PMID: 24758341
DOI: 10.1111/exd.12420

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