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Article

Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2017

Ritthipichai Krit, Haymaker Cara L, Martinez Melisa, Aschenbrenner Andrew, Yi Xiaohui, Zhang Minying, Kale Charuta, Vence Luis M, Roszik Jason, Hailemichael Yared, Overwijk Willem W, Varadarajan Navin, Nurieva Roza, Radvanyi Laszlo G, Hwu Patrick, Bernatchez Chantale

Abstract excerpt

Purpose: Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown an overall clinical response rate 40%-50% in metastatic melanoma patients. BTLA (B-and-T lymphocyte associated) expression on transferred CD8+ TILs was associated with better clinical outcome. The suppressive function of the ITIM and ITSM motifs of BTLA is well described. Here, we sought to determine the functional...

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28754817
DOI: 10.1158/1078-0432.CCR-16-1217
PMCID: PMC5748156

Genes

BTLA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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