Article

CD4⁺ T-cell reserve predicts bispecific antibody efficacy and can be enhanced by BTK inhibition in B-cell lymphoma

2026-03-03

Abstract excerpt

<title>Abstract</title> <p>Bispecific antibodies (BsAbs) targeting CD20×CD3 have achieved remarkable efficacy in relapsed or refractory (R/R) B-cell lymphoma, yet clinical responses remain heterogeneous and predictive biomarkers are lacking. In this study, we identified peripheral CD4⁺ T-cell abundance as a robust predictor of BsAb efficacy. Among 40 patients treated with CD20×CD3 BsAbs, higher baseline CD4⁺ T-ce...

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Literature Corpus work: 386b9b5c-bc4e-547e-8a3a-a57c2d3748f7
DOI: 10.21203/rs.3.rs-8819442/v1

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