Article

Targeting Breast Cancer with a Combination of DNT and LAG3 Checkpoint Blockage and its Mechanism

2021-12-06

Abstract excerpt

<title>Abstract</title> <p>Background The characteristics of the tumor immune microenvironment (TIME) are closely related to immunotherapy. Breast cancer is a highly heterogeneous tumor, and its TIME is still unclear. Methods We utilized mass cytometry to explore the immune cell heterogeneity in breast cancer. DNTs from healthy volunteers were enriched in vitro. Flow cytometry was used to detect the cell surfac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0662d33-e6aa-5750-b80d-611cd20ed42f
DOI: 10.21203/rs.3.rs-1128606/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Breast Cancer with a Combination of DNT and LAG3 Checkpoint Blockage and its MechanismDOI 10.21203/rs.3.rs-1128606/v1Read

Molecular and Clinical Characterization of LAG3 in Breast Cancer Through 2994 SamplesSemantic proximity Read

Pan-cancer and single-cell analysis reveal dual roles of lymphocyte activation gene-3 (LAG3) in cancer immunity and prognosis.Semantic proximity Read

BTN3A: A Promising Immune Checkpoint for Cancer Prognosis and TreatmentSemantic proximity Read

Current Progress and Future Perspectives of Immune Checkpoint in Cancer and Infectious DiseasesSemantic proximity Read

Exploring GZMK as a Prognostic Marker and Predictor of Immunotherapy Response in Breast Cancer: Unveiling Novel Insights into Treatment OutcomesSemantic proximity Read

The expression profiles of signature genes from CD103+LAG3+ tumour-infiltrating lymphocyte subsets predict breast cancer survivalSemantic proximity Read

Blockade of PD-1, PD-L1, and TIM-3 Altered Distinct Immune- and Cancer-Related Signaling Pathways in the Transcriptome of Human Breast Cancer ExplantsSemantic proximity Read

Double-negative T cells with a distinct transcriptomic profile are abundant in the peripheral blood of patients with breast cancerSemantic proximity Read

Lymphocyte-activation gene 3 in cancer immunotherapy: function, prognostic biomarker and therapeutic potentialsSemantic proximity Read

Expression, Prognosis, and Regulation of ULBP1, ULBP2, and ULBP3 in Human Breast CancerSemantic proximity Read

Unraveling the breast cancer tumor microenvironment: crucial factors influencing natural killer cell function and therapeutic strategiesSemantic proximity Read

LAG-3: from molecular functions to clinical applicationsSemantic proximity Read