Article

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

2023-03-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been limited due to technical challenges in isolating pure amyloid fibrils from brain extracts. <h4>Methods</h4> To investigate how amyloid fibrils form and cause neurotoxicit...

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Literature Corpus work: ea008684-ab73-5331-8a9e-c841a545cd43
DOI: 10.1101/2023.03.03.530975

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