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Article

Quantitative interaction proteomics of neurodegenerative disease proteins.

Cell reports - 19 May 2015

Hosp Fabian, Vossfeldt Hannes, Heinig Matthias, Vasiljevic Djordje, Arumughan Anup, Wyler Emanuel, Landthaler Markus, Hubner Norbert, Wanker Erich E, Lannfelt Lars, Ingelsson Martin, Lalowski Maciej, Voigt Aaron, Selbach Matthias

Abstract excerpt

Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not completely understood. Here, we used quantitative interaction proteomics to identify binding partners of Amyloid beta precursor protein (APP) and Presenilin-1 (PSEN1) for Alzheimer's disease (AD), Huntingtin (HTT) for Huntington's disease, Parkin (PARK2) for Parkinson's disease, and Ataxin-1 (ATXN1) for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25959826
DOI: 10.1016/j.celrep.2015.04.030
PMCID: PMC9014711

Genes

APP
ATXN1
HTT
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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