Article

Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment

2023-09-20

Abstract excerpt

<h4>ABSTRACT</h4> New approaches for combatting microbial infections are needed. One strategy for disrupting pathogenesis involves developing compounds that interfere with bacterial virulence. A critical molecular determinant of virulence for Gram-negative bacteria are efflux pumps of the resistance-nodulation-division (RND) family, which includes AcrAB-TolC. We previously identified small molecules that bind Acr...

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Literature Corpus work: e9f45015-15c3-571f-9760-95978adfd7f0
DOI: 10.1101/2023.09.20.558466

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