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Structural and functional analysis of the <i>Mycobacterium tuberculosis</i> MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance

2025-06-24

Abstract excerpt

Bedaquiline, an antitubercular drug that targets ATP-synthase, is a key component of a new oral drug regimen that has revolutionized the treatment of multi drug resistant tuberculosis. Clinical bedaquiline resistance in Mycobacterium tuberculosis has rapidly emerged, primarily due to mutations in the transcriptional repressor, Rv0678 that result in upregulation of the Resistance-Nodulation-Division (RND) efflux...

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Literature Corpus work
854accbe-bcbe-5c22-9fea-88e1f802a151
DOI
10.1101/2025.06.24.661325
Open publication

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Structural and functional analysis of the <i>Mycobacterium tuberculosis</i> MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistanceDOI 10.1101/2025.06.24.661325
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