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Multidrug Efflux Pumps and the Two-Faced Janus of Substrates and Inhibitors

4 Feb 2021

Abstract excerpt

Antibiotics are miracle drugs that can cure infectious bacterial diseases. However, their utility is challenged by antibiotic-resistant bacteria emerging in clinics and straining modern medicine and our ways of life. Certain bacteria such as Gram-negative (Gram(-)) and Mycobacteriales species are intrinsically resistant to most clinical antibiotics and can further gain multidrug resistance through mutations and...

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PMID: 33539084
DOI: 10.1021/acs.accounts.0c00843

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