Article

PERK inhibition rewires translational and CMGC protein kinase networks into an antiviral state

2025-10-08

Abstract excerpt

Protein kinases (PKs) are central regulators of cellular signaling, yet only a small fraction of the human kinome is targeted therapeutically, and kinase–substrate relationships remain incompletely defined. Here, we systematically characterize kinome regulation during human coronavirus 229E (HCoV-229E) infection across transcriptomic, translational, proteomic, and phospho-proteomic layers. We reveal that pharmacol...

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Literature Corpus work: e9f25c10-6ac1-505c-9560-81bc8fa74e2a
DOI: 10.1101/2025.10.08.681090

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