Article

Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung Derived Cell Lines

2024-09-26

Abstract excerpt

<h4>ABSTRACT</h4> The betacoronavirus genus contains five of the seven human viruses, making it a particularly critical area of research to prepare for future viral emergence. We utilized three human betacoronaviruses, one from each subgenus-HCoV-OC43 (embecovirus), SARS-CoV-2 (sarbecovirus) and MERS-CoV (merbecovirus)- to study betacoronavirus interaction with the PKR-like ER kinase (PERK) pathway of the integra...

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Literature Corpus work: 57796ce4-396c-51f7-8172-7aec90c16b6e
DOI: 10.1101/2024.09.25.614975

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