Article

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

2022-01-04

Abstract excerpt

<h4>ABSTRACT</h4> Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the set of inhibitors correlated with antiviral activity and genetic knockdown confirmed the essential role of the CSNK2 holoenzyme in β-coronavirus rep...

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Literature Corpus work: 5f7d6c7a-fad0-503c-8448-8fa0cb6f9241
DOI: 10.1101/2022.01.03.474779

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