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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

1 May 2025

Abstract excerpt

Upon infection, viruses alter the proteome, creating a hospitable environment for infection. Cells respond to limit viral replication, including through protein regulation by post-translational modifications. We use mass spectrometry to define proteome alterations during West Nile virus (WNV) infection. Our studies identify upregulation of HERPUD1, which restricts WNV replication through a mechanism independent...

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PMID: 40381193
DOI: 10.1016/j.celrep.2025.115728

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