Article
TGF-beta and epithelial-to-mesenchymal transitions.
Oncogene - 29 Aug 2005
Zavadil Jiri, Böttinger Erwin P
Abstract excerpt
Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular mediators that control epithelial plasticity will be required in order to develop viable therapeutic approaches targeting epithelial-to-mesenchymal transition (EMT), an advanced manifestation of epithelial plasticity. Members of the...
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