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La-related protein 4 is enriched in vaccinia virus factories and is required for efficient viral replication in primary human fibroblasts

2023-03-11

Abstract excerpt

In addition to the 3’-poly(A) tail, vaccinia virus mRNAs synthesized after viral DNA replication (post-replicative mRNAs) possess a 5’-poly(A) leader that confers a translational advantage in virally infected cells. These mRNAs are synthesized in viral factories, the cytoplasmic compartment where vaccinia virus DNA replication, mRNA synthesis, and translation occur. However, a previous study indicates that the pol...

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Identifiers and source

Literature Corpus work
e9d25dfa-f2aa-5178-a56f-139f61cee351
DOI
10.1101/2023.03.10.532125
Open publication

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La-related protein 4 is enriched in vaccinia virus factories and is required for efficient viral replication in primary human fibroblastsDOI 10.1101/2023.03.10.532125
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