Article
Quantitative Analysis of MicroRNAs in Vaccinia virus Infection Reveals Diversity in Their Susceptibility to Modification and Suppression.
PloS one - 1 Jan 2015
Buck Amy H, Ivens Alasdair, Gordon Katrina, Craig Nicola, Houzelle Alexandre, Roche Alice, Turnbull Neil, Beard Philippa M
Abstract excerpt
Vaccinia virus (VACV) is a large cytoplasmic DNA virus that causes dramatic alterations to many cellular pathways including microRNA biogenesis. The virus encodes a poly(A) polymerase which was previously shown to add poly(A) tails to the 3' end of cellular miRNAs, resulting in their degradation by 24 hours post infection (hpi). Here we used small RNA sequencing to quantify the impact of VACV infection on...
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