Article

Spatio-temporal analysis of Vaccinia virus infection and host response dynamics using single-cell transcriptomics and proteomics

2024-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Poxviruses are a large group of DNA viruses with exclusively cytoplasmic life cycles and complex gene expression programs. A number of systems-level studies have analyzed bulk transcriptome and proteome changes upon poxvirus infection, but the cell-to-cell heterogeneity of the transcriptomic response, and the subcellular resolution of proteomic changes have remained unexplored. Here, we measured...

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Literature Corpus work: 800654ee-0071-50ea-acd0-6efe5b76ec42
DOI: 10.1101/2024.01.13.575413

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