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Article

Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus.

PloS one - 1 Jan 2014

Tahiri-Alaoui Abdessamad, Zhao Yuguang, Sadigh Yashar, Popplestone James, Kgosana Lydia, Smith Lorraine P, Nair Venugopal

Abstract excerpt

Poly(A) binding protein 1 (PABP1) plays a central role in mRNA translation and stability and is a target by many viruses in diverse manners. We report a novel viral translational control strategy involving the recruitment of PABP1 to the 5' leader internal ribosome entry site (5L IRES) of an immediate-early (IE) bicistronic mRNA that encodes the neurovirulence protein (pp14) from the avian herpesvirus Marek's...

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Identifiers

PMID: 25503397
DOI: 10.1371/journal.pone.0114466
PMCID: PMC4263670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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