Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus.

doi:10.1371/journal.pone.0114466

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Article

Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus.

PloS one - 1 Jan 2014

Tahiri-Alaoui Abdessamad, Zhao Yuguang, Sadigh Yashar, Popplestone James, Kgosana Lydia, Smith Lorraine P, Nair Venugopal

Abstract excerpt

Poly(A) binding protein 1 (PABP1) plays a central role in mRNA translation and stability and is a target by many viruses in diverse manners. We report a novel viral translational control strategy involving the recruitment of PABP1 to the 5' leader internal ribosome entry site (5L IRES) of an immediate-early (IE) bicistronic mRNA that encodes the neurovirulence protein (pp14) from the avian herpesvirus Marek's...

Topics

Animals
Base Sequence
Cell Line
Chickens
Gene Expression Regulation
Herpesvirus 2, Gallid
Humans
MicroRNAs
Molecular Sequence Data
Mutagenesis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Chain Initiation, Translational

Poly A

Poly(A)-Binding Protein I

Protein Transport

RNA, Messenger

RNA-Binding Proteins

Viral Proteins

Source

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Identifiers

PMID: 25503397
DOI: 10.1371/journal.pone.0114466
PMCID: PMC4263670

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