Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication

Abstract excerpt

Ebola virus (EBOV) critically depends on the viral polymerase to replicate and transcribe the viral RNA genome in the cytoplasm of host cells, where cellular factors can antagonize or facilitate the virus life cycle. Here we leverage proximity proteomics and conduct a small interfering RNA (siRNA) screen to define the functional interactome of EBOV polymerase. As a proof of principle, we validate two cellular...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Respiratory viral infections research
• Share to Viral Infections and Outbreaks Research
• Share to Virus-based gene therapy research