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Article

Subgroup-specific gene expression profiles and mixed epistasis in chronic lymphocytic leukemia.

Haematologica - 1 Oct 2023

Lütge Almut, Lu Junyan, Hüllein Jennifer, Walther Tatjana, Sellner Leopold, Wu Bian, Rosenquist Richard, Oakes Christopher C, Dietrich Sascha, Huber Wolfgang, Zenz Thorsten

Abstract excerpt

Understanding the molecular and phenotypic heterogeneity of cancer is a prerequisite for effective treatment. For chronic lymphocytic leukemia (CLL), recurrent genetic driver events have been extensively cataloged, but this does not suffice to explain the disease's diverse course. Here, we performed RNA sequencing on 184 CLL patient samples. Unsupervised analysis revealed two major, orthogonal axes of gene...

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Share to Chronic Lymphocytic Leukemia Research
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation and Glycoproteins Research

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 37226709
DOI: 10.3324/haematol.2022.281869
PMCID: PMC10614035

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