Integrated Antitumor Activities of Cellular Immunotherapy with CIK Lymphocytes and Interferons against KIT/PDGFRA Wild Type GIST.

doi:10.3390/ijms231810368

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Article

Integrated Antitumor Activities of Cellular Immunotherapy with CIK Lymphocytes and Interferons against KIT/PDGFRA Wild Type GIST.

International journal of molecular sciences - 8 Sept 2022

Fiorino Erika, Merlini Alessandra, D'Ambrosio Lorenzo, Cerviere Ilaria, Berrino Enrico, Marchiò Caterina, Giraudo Lidia, Basiricò Marco, Massa Annamaria, Donini Chiara, Leuci Valeria, Rotolo Ramona, Galvagno Federica, Vitali Letizia, Proment Alessia, Ferrone Soldano, Pisacane Alberto, Pignochino Ymera, Aglietta Massimo, Grignani Giovanni, Mesiano Giulia, Sangiolo Dario

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are rare, mesenchymal tumors of the gastrointestinal tract, characterized by either KIT or PDGFRA mutation in about 85% of cases. KIT/PDGFRA wild type gastrointestinal stromal tumors (wtGIST) account for the remaining 15% of GIST and represent an unmet medical need: their prevalence and potential medical vulnerabilities are not completely defined, and effective therapeutic...

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PMID: 36142281
DOI: 10.3390/ijms231810368
PMCID: PMC9499671

Genes

KIT
PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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