Article

Single time-point multi-dimensional biomarker models can predict acute organ injury trajectory

2025-10-07

Abstract excerpt

<h4>Background</h4> Forecasting acute organ injury trajectory remains a critical clinical challenge. Current approaches rely on serial measurements, delaying decision-making. Using paracetamol-induced liver injury (APAP DILI) as a model, we developed and validated a machine learning framework integrating mechanistically distinct biomarkers to predict injury trajectory from a single timepoint. <h4>Methods</h4> We...

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Literature Corpus work: e98e4bfb-63db-5772-b989-df49c471a0f0
DOI: 10.1101/2025.10.06.25337429

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