Article

Decoding MASLD Progression: A Molecular Trajectory-Based Framework for Modelling Disease Dynamics

2025-01-18

Abstract excerpt

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has emerged as a silent pandemic, affecting nearly one-third of the global population. MASLD encompasses a spectrum of liver disorders, ranging from simple steatosis to Metabolic Dysfunction-Associated Steatohepatitis (MASH), characterised by lipotoxicity, hepatocellular injury, inflammation, and fibrosis, which can eventually progress to cirrhosis a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c3c7c2f5-bedf-5358-a230-a076d96e7beb
DOI: 10.1101/2025.01.14.632908

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding MASLD Progression: A Molecular Trajectory-Based Framework for Modelling Disease DynamicsDOI 10.1101/2025.01.14.632908Read

MegaMASLD: An interactive platform for exploring stratified transcriptomic signatures in MASLD progressionSemantic proximity Read

A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liverSemantic proximity Read

A proteo-transcriptomic map of non-alcoholic fatty liver disease signaturesSemantic proximity Read

Identification of signature gene set as highly accurate determination of metabolic dysfunction-associated steatotic liver disease progressionSemantic proximity Read

Global molecular landscape of early MASLD progression in obesitySemantic proximity Read

SteatoSITE: an Integrated Gene-to-Outcome Data Commons for Precision Medicine Research in NAFLDSemantic proximity Read

Metabolic Rewiring in MASLD: From Disease Mechanisms to Precision MedicineSemantic proximity Read

Unraveling MASLD Through the Use of Omics TechnologiesSemantic proximity Read

Molecular Clustering of Metabolic Dysfunction-Associated Steatotic Liver Disease Based on Transcriptome AnalysisSemantic proximity Read

Sex-specific lipid-mediated mechanisms drive MASLD progression revealed by paired liver–blood multi-omicsSemantic proximity Read

Mapping the genomic landscape of MASLD: A framework for molecular subtyping and precision hepatology.Semantic proximity Read

Integrative multi-omics and multi-trait analysis prioritizes regulatory mechanisms and genes for metabolic dysfunction-associated steatotic liver diseaseSemantic proximity Read