Development and validation of dynamic clinical subphenotypes for acute pancreatitis using hematocrit and blood urea nitrogen trajectories in intensive care unit: a multicenter retrospective cohort study.

doi:10.1016/j.jare.2026.01.004

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Article

Development and validation of dynamic clinical subphenotypes for acute pancreatitis using hematocrit and blood urea nitrogen trajectories in intensive care unit: a multicenter retrospective cohort study.

Journal of advanced research - 1 Sept 2026

Wan Jianhua, Kuang Maobin, Xiong Shixuan, Zou Yaoyu, Ke Huajing, He Wenhua, Zhu Yin, Lu Nonghua, Xia Liang

Abstract excerpt

BACKGROUND: Acute Pancreatitis (AP) is a common gastrointestinal emergency in which early fluid therapy is critical, yet optimal strategies remain debated. Although Hematocrit (HCT) and Blood Urea Nitrogen (BUN) are recommended to guide fluid management, the prognostic value of their dynamic changes is unclear. METHODS: This multicenter retrospective cohort study utilized a development cohort from Jiangxi...

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PMID: 41485572
DOI: 10.1016/j.jare.2026.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.