Circulating Lipids Predict Mortality and Drive Immune Gene Regulation in Acute-on-Chronic Liver Failure

Abstract excerpt

<title>Abstract</title> <p> Background: Acute-on-chronic liver failure (ACLF) has ~ 50% 28-day mortality driven by systemic inflammation, immune dysfunction, and multiorgan failure. The contribution of circulating lipids to ACLF pathogenesis remains poorly understood. We investigated whether plasma lipid signatures predict short-term mortality and participate in immune dysregulation in ACLF. <h4>Methods:</h4> Ta...

Topics

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• Albumins
• Fibrosis
• Hypertension, Portal
• Immune System
• Immunosuppression Therapy
• Liver Disease and Transplantation
• Liver Disease Diagnosis and Treatment
• Organ Transplantation Techniques and Outcomes

Identifiers and source

Literature Corpus work

4694f1ce-f2e0-5cf9-954a-c341c56b4474

DOI

10.21203/rs.3.rs-8154019/v1