Article
A novel protective prion protein variant that colocalizes with kuru exposure.
The New England journal of medicine - 19 Nov 2009
Mead Simon, Whitfield Jerome, Poulter Mark, Shah Paresh, Uphill James, Campbell Tracy, Al-Dujaily Huda, Hummerich Holger, Beck Jon, Mein Charles A, Verzilli Claudio, Whittaker John, Alpers Michael P, Collinge John
Abstract excerpt
BACKGROUND: Kuru is a devastating epidemic prion disease that affected a highly restricted geographic area of the Papua New Guinea highlands; at its peak, it predominantly affected adult women and children of both sexes. Its incidence has steadily declined since the cessation of its route of transmission, endocannibalism. METHODS: We performed genetic and selected clinical and genealogic assessments of more than...
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