Article

Progression of fiber bundle damage in amnestic Alzheimer’s disease and LATE: a 2-year fixel-based study

2025-09-07

Abstract excerpt

Alzheimer’s disease (AD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) are two neurodegenerative diseases underpinned by distinct proteinopathies, which share a similar initial amnestic clinical phenotype but have a different clinical course. Some pathophysiological models suggest a role for white matter (WM) fiber bundles in disease progression, but they remain discussed, as does their applicabi...

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Literature Corpus work: e9686b63-6365-5524-a003-19f54cc7fab6
DOI: 10.1101/2025.09.05.25333680

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