Article

Integrated combinatorial functional genomics and spatial transcriptomics of tumors decodes genotype to phenotype relationships

2024-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Linking the complex genetic changes underlying cancer to relevant disease-phenotypes poses a challenge. Therefore, we present CHOCOLAT-G2P, a scalable approach that integrates multiplex in vivo functional genomics with spatial transcriptomics. By redeploying RNA-templated ligation probes of commercial spatial transcriptomics technology, we streamline mapping composite genetic alterations and tra...

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Literature Corpus work: e95e4507-ac33-5ad7-8307-d4c3634d886a
DOI: 10.1101/2024.05.14.593940

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