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STGBench: sequencing-level spatial DNA-RNA simulation for multimodal and virtual cell-oriented benchmarking of genomic alterations.

Briefings in bioinformatics - 3 Jul 2026

Wang Shenjie, Li Yuhang, Wang Xiaonan, Wang Xuwen, Wang Tianci, Yang Shuanying, Wang Jiayin

Abstract excerpt

Spatially resolved genomics and transcriptomics are reshaping our understanding of tumor evolution and therapeutic resistance, yet benchmarking spatial copy number variation (CNV), single-nucleotide variant (SNV), and spatial mutation-burden proxy analyses is constrained by the scarcity of datasets with known ground truth. Existing simulators often produce only count matrices, lack matched DNA-RNA outputs, or do...

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PMID: 42418828
DOI: 10.1093/bib/bbag354
PMCID: PMC13345378

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