SP-printer: reconstruction of tumor stage-specific microenvironments via phenotype-integrated spatial transcriptomics.

Abstract excerpt

BACKGROUND: Spatial transcriptomics (ST) technologies have rapidly advanced the investigation of tumor microenvironment (TME) mechanisms by enabling high-resolution mapping of mRNA molecules within their native spatial context. However, existing methods often overlook phenotypic indices like malignancy status, limiting their interpretability within the tumor microenvironment. METHODS: This work proposes...

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