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High mobility group box 1 (HMGB1) phenotypic role revealed with stress.

Molecular medicine (Cambridge, Mass.) - 19 Aug 2014

Tang Daolin, Kang Rui, Van Houten Bennett, Zeh Herbert J, Billiar Timothy R, Lotze Michael T

Abstract excerpt

High mobility group box 1 (HMGB1) is an evolutionarily ancient protein that is present in one form or another in all eukaryotes. It fundamentally resides in the nucleus but translocates to the cytosol with stress and is subsequently released into the extracellular space. HMGB1 global knockout mice exhibit lethal hypoglycemia, whereas tissues and cells from conditional knockout or knock-in mice are born alive...

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Advanced Glycation End Products research
Alcohol Consumption and Health Effects
Autophagy
HMGB1 gene
HMGB1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stress, Physiological

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PMID: 24937773
DOI: 10.2119/molmed.2014.00063
PMCID: PMC4153844

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HMGB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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