Article

Retromer Combinatorials for Gene-Therapy Across a Spectrum of Neurological Diseases

2020-09-04

Abstract excerpt

<h4>ABSTRACT</h4> Endosomal trafficking is a biological pathway implicated in Alzheimer’s and Parkinson’s disease, and a growing number of other neurological disorders. For this category of diseases, the endosome’s trafficking complex retromer has emerged as a validated therapeutic target. Retromer’s core is a heterotrimeric complex composed of the scaffold protein VPS35 to which VPS26 and VPS29 bind. Unless it i...

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Literature Corpus work: e94ac164-55d6-5278-9136-7eea7a8a9e77
DOI: 10.1101/2020.09.03.282327

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