Article

Structure informed xrRNA2 mutations in Zika virus provide a roadmap for vaccine development

2026-05-29

Abstract excerpt

Flaviviruses like Zika virus (ZIKV), contain RNA tertiary structures within the 3’ untranslated region (UTR) that halt the 5’-to-3’ RNA exonuclease, Xrn1. Halting of Xrn1 at the two RNA structures, termed exonuclease-resistantRNA1 and 2 (xrRNA1 and xrRNA2), results in the formation of subgenomic flavivirus RNAs (sfRNA) that support viral pathogenesis. While the role of the flavivirus xrRNA1 in pathogenesis is well...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e94a6525-45a3-5678-850e-bc6c970f0dbd
DOI: 10.64898/2026.05.27.728262

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure informed xrRNA2 mutations in Zika virus provide a roadmap for vaccine developmentDOI 10.64898/2026.05.27.728262Read

Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication.Semantic proximity Read

Disruption of Zika virus xrRNA1-dependent sfRNA1 production results in tissue-specific attenuated viral replicationSemantic proximity Read

Determinant host differences in ZIKV sfRNA accumulationSemantic proximity Read

Functional RNA during Zika virus infectionSemantic proximity Read

Zika virus dumbbell-1 structure is critical for sfRNA presence and cytopathic effect during infectionSemantic proximity Read

Comparative analysis of flavivirus sfRNA dynamics and secondary structureSemantic proximity Read

Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.Semantic proximity Read

RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA.Semantic proximity Read

Tick-borne flavivirus exoribonuclease-resistant RNAs contain a ‘double loop’ structureSemantic proximity Read

Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitorsSemantic proximity Read

Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAsSemantic proximity Read

Zika Virus NS2A-Mediated Virion Assembly.Semantic proximity Read