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Article

Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.

Science (New York, N.Y.) - 2 Dec 2016

Akiyama Benjamin M, Laurence Hannah M, Massey Aaron R, Costantino David A, Xie Xuping, Yang Yujiao, Shi Pei-Yong, Nix Jay C, Beckham J David, Kieft Jeffrey S

Abstract excerpt

The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce noncoding subgenomic flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice. These viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called xrRNAs. We found that ZIKV-infected monkey and human epithelial...

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Identifiers

PMID: 27934765
DOI: 10.1126/science.aah3963
PMCID: PMC5476369

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