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Article

Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication.

Viruses - 18 Oct 2020

Sparks Hadrian, Monogue Brendan, Akiyama Benjamin, Kieft Jeffrey, Beckham J David

Abstract excerpt

The Zika virus (ZIKV), like other flaviviruses, produces several species of sub-genomic RNAs (sfRNAs) during infection, corresponding to noncoding RNA fragments of different lengths that result from the exonuclease degradation of the viral 3' untranslated region (UTR). Over the course of infection, these sfRNAs accumulate in the cell as a result of an incomplete viral genome degradation of the 3' UTR by the host...

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PMID: 33080971
DOI: 10.3390/v12101177
PMCID: PMC7589627

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