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Zika Virus NS2A-Mediated Virion Assembly.

mBio - 29 Oct 2019

Zhang Xianwen, Xie Xuping, Xia Hongjie, Zou Jing, Huang Linfen, Popov Vsevolod L, Chen Xinwen, Shi Pei-Yong

Abstract excerpt

The flavivirus virion consists of an envelope outer layer, formed by envelope (E) and membrane (M) proteins on a lipid bilayer, and an internal core, formed by capsid (C) protein and genomic RNA. The molecular mechanism of flavivirus assembly is not well understood. Here, we show that Zika virus (ZIKV) NS2A protein recruits genomic RNA, the structural protein prM/E complex, and the NS2B/NS3 protease complex to...

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Flavivirus
Nucleocapsid
Peptide Hydrolases
Serine Endopeptidases
Viral Nonstructural Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Zika Virus Infection

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Identifiers

PMID: 31662457
DOI: 10.1128/mBio.02375-19
PMCID: PMC6819661

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