Article

Determinant host differences in ZIKV sfRNA accumulation

2025-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Zika virus ( Orthoflavivirus zikaese) is part of the Orthoflavivirus genus that contains several viral species posing major and expanding burdens to public health worldwide. Upon infection, orthoflaviviruses produce viral RNA fragments named sfRNAs (short flaviviral RNA), generated from viral genomic RNA incompletely degraded by Xrn1/Pcm, the major cellular 5’-3’ exonuclease. Several conserved...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9031417-8f56-5420-9b88-b9a141edc5ff
DOI: 10.1101/2025.11.17.688941

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Determinant host differences in ZIKV sfRNA accumulationDOI 10.1101/2025.11.17.688941Read

Disruption of Zika virus xrRNA1-dependent sfRNA1 production results in tissue-specific attenuated viral replicationSemantic proximity Read

Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication.Semantic proximity Read

Structure informed xrRNA2 mutations in Zika virus provide a roadmap for vaccine developmentSemantic proximity Read

Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinant of sfRNA biogenesis and provides new insights into flavivirus evolutionSemantic proximity Read

Pan-flavivirus analysis reveals sfRNA-independent, 3′ UTR-biased siRNA production from an insect-specific flavivirusSemantic proximity Read

Comparative analysis of flavivirus sfRNA dynamics and secondary structureSemantic proximity Read

The subgenomic flaviviral RNA suppresses RNA interference through competing with siRNAs for binding RISC componentsSemantic proximity Read

Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAsSemantic proximity Read

Zika virus dumbbell-1 structure is critical for sfRNA presence and cytopathic effect during infectionSemantic proximity Read

Zika Virus Subgenomic Flavivirus RNA Generation Requires Cooperativity between Duplicated RNA Structures That Are Essential for Productive Infection in Human CellsSemantic proximity Read

Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infectionSemantic proximity Read

Zika virus non-coding RNAs antagonize antiviral responses by PKR-mediated translational arrestSemantic proximity Read