Article
RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA.
eLife - 1 Apr 2014
Chapman Erich G, Moon Stephanie L, Wilusz Jeffrey, Kieft Jeffrey S
Abstract excerpt
Dengue virus is a growing global health threat. Dengue and other flaviviruses commandeer the host cell's RNA degradation machinery to generate the small flaviviral RNA (sfRNA), a noncoding RNA that induces cytopathicity and pathogenesis. Host cell exonuclease Xrn1 likely loads on the 5' end of viral genomic RNA and degrades processively through ∼10 kB of RNA, halting near the 3' end of the viral RNA. The...
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