Article

Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia

2025-04-24

Abstract excerpt

Cancer stem cells (CSCs) are hypothesized to promote tumor progression through innate chemoresistance and self-renewal. CSCs reside in the CD34 + /CD38 - immunophenotypic subpopulation of acute myeloid leukemia (AML); correspondingly, the size of this subpopulation has a strong negative impact on overall survival. Isolation of CSCs from B-lymphoblastic leukemia (B-ALL) has proven difficult, and the cells of inte...

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Literature Corpus work: 70688062-7f21-52ae-8321-7141289a7fbb
DOI: 10.1101/2025.04.21.649796

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