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State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia

2 Feb 2024

Abstract excerpt

Chronic myeloid leukemia (CML) is initiated and maintained by BCR::ABL which is clinically targeted using tyrosine kinase inhibitors (TKIs). TKIs can induce long-term remission but are also not curative. Thus, CML is an ideal system to test our hypothesis that transcriptome-based state-transition models accurately predict cancer evolution and treatment response. We collected time-sequential blood samples from...

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PMID: 38307941
DOI: 10.1038/s41375-024-02142-9

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