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CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg-/- Mice Results in Severe Immunodeficiency.

Scientific reports - 10 Aug 2017

Wei Xinru, Lai Yunxin, Li Baiheng, Qin Le, Xu Youdi, Lin Simiao, Wang Suna, Wu Qiting, Liang Qiubin, Huang Guohua, Deng Qiuhua, Liu Pentao, Wu Donghai, Lai Liangxue, Yao Yao, Li Peng

Abstract excerpt

Immunodeficient mice engrafted with either normal or cancerous human cells are widely used in basic and translational research. In particular, NOD/SCID/IL2rg-/- mice can support the growth of various types of human cancer cells. However, the hairs of these mice interfere with the observation and imaging of engrafted tissues. Therefore, novel hairless strains exhibiting comparable immunodeficiency would be...

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Identifiers

PMID: 28798321
DOI: 10.1038/s41598-017-08337-8
PMCID: PMC5552779

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NOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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