Transgenic expression of human signal regulatory protein alpha in Rag2 ^−/− γ _c ^−/− mice improves engraftment of human hematopoietic cells in humanized mice

Abstract excerpt

Transplantation of human hematopoietic stem cells into severely immunocompromised newborn mice allows the development of a human hematopoietic and immune system in vivo. NOD/scid/γ(c)(-/-) (NSG) and BALB/c Rag2(-/-)γ(c)(-/-) mice are the most commonly used mouse strains for this purpose and a number of studies have demonstrated the high value of these model systems in areas spanning from basic to translational...

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