Article

The Convergence of Senescence and Ferroptosis Amplifies DNA Damage and Triggers Apoptosis in Patient-Derived Melanoma Models

2026-05-20

Abstract excerpt

<title>Abstract</title> <p> Therapy-induced senescence (TIS) is a common response to anticancer treatment that enforces durable cell-cycle arrest but can also promote tumor persistence and disease relapse if senescent cells are not efficiently eliminated. The “one–two punch” therapeutic paradigm aims to overcome this limitation by coupling senescence induction with senolytic targeting. In this study, using disti...

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Literature Corpus work: e92ee182-e041-5451-b820-5e929914a09c
DOI: 10.21203/rs.3.rs-9577216/v1

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